2goo Summary

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Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD

The structure was published by Allendorph, G.P., Vale, W.W., and Choe, S., in 2006 in a paper entitled "Structure of the ternary signaling complex of a TGF-beta superfamily member." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, and Activin receptor type 2A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bone morphogenetic protein 2 P12643 (283-396) (BMP2_HUMAN)search Homo sapienssearch < 90% 114 91%
D Bone morphogenetic protein 2 P12643 (283-396) (BMP2_HUMAN)search Homo sapienssearch < 90% 114 91%
B Bone morphogenetic protein receptor type IA P36894 (24-152) (BMR1A_HUMAN)search Homo sapienssearch < 90% 131 67%
E Bone morphogenetic protein receptor type IA P36894 (24-152) (BMR1A_HUMAN)search Homo sapienssearch < 90% 131 67%
C Activin receptor type 2A P27038 (20-121) (AVR2A_MOUSE)search Mus musculussearch < 90% 102 91%
F Activin receptor type 2A P27038 (20-121) (AVR2A_MOUSE)search Mus musculussearch < 90% 102 91%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P12643 (283 - 396) Bone morphogenetic protein 2 Homo sapiens
P36894 (24 - 152) Bone morphogenetic protein receptor type IA Homo sapiens
P27038 (20 - 121) Activin receptor type 2A Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D Transforming growth factor (TGF)-betasearch Cystine-knot cytokinessearch Transforming growth factor beta like domainsearch
B, E Extracellular domain of cell surface receptorssearch CD59search Activin types I and II receptor domainsearch
C, F Extracellular domain of cell surface receptorssearch CD59search Activin types I and II receptor domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, D (P12643) growth factor activitysearch extracellular regionsearch
B, E (P36894) ATP bindingsearch receptor signaling protein serine/threonine kinase activitysearch transmembrane receptor protein serine/threonine kinase activitysearch transforming growth factor beta-activated receptor activitysearch membranesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch
C, F (P27038) transforming growth factor beta-activated receptor activitysearch ATP bindingsearch transmembrane receptor protein serine/threonine kinase activitysearch receptor signaling protein serine/threonine kinase activitysearch membranesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch

Chain InterPro annotation
A, D Transforming growth factor-beta, C-terminalsearch Inhibin, alpha subunitsearch Transforming growth factor-beta-relatedsearch Transforming growth factor beta, conserved sitesearch Cystine-knot cytokinesearch
B, E Ser/Thr protein kinase, TGFB receptorsearch TGF-beta receptor/activin receptor, type I/IIsearch
C, F Ser/Thr protein kinase, TGFB receptorsearch TGF-beta receptor/activin receptor, type I/IIsearch