Function and Biology Details
Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ser/Thr protein kinase, TGFB receptor
- Snake toxin-like superfamily
- Transforming growth factor-beta, C-terminal
- Activin types I and II receptor domain
- Cystine-knot cytokine
- Transforming growth factor beta, conserved site
- Bone morphogenetic protein 2, TGF-beta-like domain
- Transforming growth factor-beta-related
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-146280 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Bone morphogenetic protein 2
Molecule details ›
Chains: A, D
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P12643 (Residues: 283-396; Coverage: 31%)
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Bone morphogenetic protein receptor type-1A
Molecule details ›
Chains: B, E
Length: 131 amino acids
Theoretical weight: 14.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59
Length: 131 amino acids
Theoretical weight: 14.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P36894 (Residues: 24-152; Coverage: 25%)
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59
Activin receptor type-2A
Molecule details ›
Chains: C, F
Length: 102 amino acids
Theoretical weight: 12.02 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59
Length: 102 amino acids
Theoretical weight: 12.02 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
- Canonical: P27038 (Residues: 20-121; Coverage: 21%)
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59
