2gl7 Summary

pdbe.org/2gl7
spacer

Crystal Structure of a beta-catenin/BCL9/Tcf4 complex

The structure was published by Sampietro, J., Dahlberg, C.L., Cho, U.S., Hinds, T.R., Kimelman, D., and Xu, W., in 2006 in a paper entitled "Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Beta-catenin, Transcription factor 7-like 2, and B-cell lymphoma 9 protein.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Beta-catenin P35222 (138-686) (CTNB1_HUMAN)search Homo sapienssearch < 90% 550 93%
D Beta-catenin P35222 (138-686) (CTNB1_HUMAN)search Homo sapienssearch < 90% 550 93%
B Transcription factor 7-like 2 Q9NQB0 (1-53) (TF7L2_HUMAN)search Homo sapienssearch < 90% 53 56%
E Transcription factor 7-like 2 Q9NQB0 (1-53) (TF7L2_HUMAN)search Homo sapienssearch < 90% 53 56%
C B-cell lymphoma 9 protein O00512 (347-392) (BCL9_HUMAN)search Homo sapienssearch < 90% 46 50%
F B-cell lymphoma 9 protein O00512 (347-392) (BCL9_HUMAN)search Homo sapienssearch < 90% 46 50%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P35222 (138 - 686) Beta-catenin Homo sapiens
Q9NQB0 (1 - 53) Transcription factor 7-like 2 Homo sapiens
O00512 (347 - 392) B-cell lymphoma 9 protein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
B, E N-terminal CTNNB1 bindingsearch
C, F B-cell lymphoma 9 proteinsearch

Chain ID Biological process (GO)
B, E (Q9NQB0) Wnt signaling pathwaysearch

Chain InterPro annotation
A, D Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
B, E CTNNB1 binding, N-teminalsearch Transcription factor TCF/LEFsearch Catenin binding domainsearch
C, F B Cell Lymphoma 9search B-cell lymphoma 9, beta-catenin binding domainsearch