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Crystal Structure of a beta-catenin/BCL9/Tcf4 complex

X-ray diffraction
2.6Å resolution
PDB entry 2gl7 coloured by chain, front view.
PDB entry 2gl7 coloured by chain, side view.
PDB entry 2gl7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 23963.08 Å2
Buried surface area: 4613.51 Å2
Dissociation area: 604.83 Å2
Dissociation energy (ΔGdiss): 7.39 kcal/mol
Dissociation entropy (TΔSdiss): 8.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126328
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 23705.99 Å2
Buried surface area: 4024.84 Å2
Dissociation area: 396.74 Å2
Dissociation energy (ΔGdiss): 1.29 kcal/mol
Dissociation entropy (TΔSdiss): 8.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126328

Macromolecules

Catenin beta-1
Chains: A, D
Length: 550 amino acids
Theoretical weight: 60.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 138-686; Coverage: 70%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Pfam: Armadillo/beta-catenin-like repeat
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: Armadillo repeat
Catenin beta-1 in PDB entry 2gl7, assembly 1, front view.
Catenin beta-1 in PDB entry 2gl7, assembly 1, side view.
Catenin beta-1 in PDB entry 2gl7, assembly 1, top view.
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Transcription factor 7-like 2
Chains: B, E
Length: 53 amino acids
Theoretical weight: 5.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQB0 (Residues: 1-53; Coverage: 9%)
Gene names: TCF4, TCF7L2
InterPro:
Transcription factor 7-like 2 in PDB entry 2gl7, assembly 1, front view.
Transcription factor 7-like 2 in PDB entry 2gl7, assembly 1, side view.
Transcription factor 7-like 2 in PDB entry 2gl7, assembly 1, top view.
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B-cell CLL/lymphoma 9 protein
Chains: C, F
Length: 46 amino acids
Theoretical weight: 5.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00512 (Residues: 347-392; Coverage: 3%)
Gene name: BCL9
Pfam: B-cell lymphoma 9 protein
InterPro:
B-cell CLL/lymphoma 9 protein in PDB entry 2gl7, assembly 1, front view.
B-cell CLL/lymphoma 9 protein in PDB entry 2gl7, assembly 1, side view.
B-cell CLL/lymphoma 9 protein in PDB entry 2gl7, assembly 1, top view.
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