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HincII bound to cognate DNA GTTAAC

Source organism: Haemophilus influenzae
Biochemical function: type II site-specific deoxyribonuclease activity
Biological process: DNA restriction-modification system
Cellular component: not assigned

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EC 3.1.21.4: Type II site-specific deoxyribonuclease

Reaction catalysed:
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates
Systematic name:
-
Alternative Name(s):
  • Type II restriction enzyme

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF09226
Domain description: Restriction endonuclease HincII
Occurring in:
  1. Type II restriction enzyme HincII
The deposited structure of PDB entry 2gie contains 4 copies of Pfam domain PF09226 (Restriction endonuclease HincII) in Type II restriction enzyme HincII. Showing 1 copy in chain E [auth A].

InterPro InterPro annotations
IPR015307
Domain description: Restriction endonuclease, type II, HincII
Occurring in:
  1. Type II restriction enzyme HincII
IPR037057
Domain description: DNA mismatch repair MutH/Type II restriction endonuclease superfamily
Occurring in:
  1. Type II restriction enzyme HincII
IPR011335
Domain description: Restriction endonuclease type II-like
Occurring in:
  1. Type II restriction enzyme HincII

Structure domain

CATH CATH domain
3.40.600.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: ECO RV Endonuclease; Chain A
Homology: DNA mismatch repair MutH/Restriction endonuclease, type II
Occurring in:
  1. Type II restriction enzyme HincII
The deposited structure of PDB entry 2gie contains 4 copies of CATH domain 3.40.600.10 (ECO RV Endonuclease; Chain A) in Type II restriction enzyme HincII. Showing 1 copy in chain E [auth A].
SCOP SCOP annotation
69525
Class: Alpha and beta proteins (a/b)
Fold: Restriction endonuclease-like
Superfamily: Restriction endonuclease-like
Occurring in:
  1. Type II restriction enzyme HincII
The deposited structure of PDB entry 2gie contains 4 copies of SCOP domain 69525 (Restriction endonuclease HincII) in Type II restriction enzyme HincII. Showing 1 copy in chain E [auth A].

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