2ghl Summary


Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743

The structure was published by Brugel, T.A., Maier, J.A., Clark, M.P., et al., Hsieh, L.C., Mekel, M.J., and Janusz, M.J., in 2006 in a paper entitled "Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.099 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 333 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (5-352) (MK14_MOUSE)search Mus musculussearch 97% 348 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (5 - 352) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P47811) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P47811) protein kinase activitysearch transferase activitysearch protein bindingsearch MAP kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch NFAT protein bindingsearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch cellsearch mitochondrionsearch cytosolsearch nucleussearch cytoplasmsearch extracellular vesicular exosomesearch spindle polesearch cellular response to DNA damage stimulussearch response to lipopolysaccharidesearch cellular response to ionizing radiationsearch negative regulation of canonical Wnt signaling pathwaysearch protein phosphorylationsearch stress-induced premature senescencesearch peptidyl-serine phosphorylationsearch phosphorylationsearch chondrocyte differentiationsearch osteoclast differentiationsearch DNA damage checkpointsearch skeletal muscle tissue developmentsearch positive regulation of reactive oxygen species metabolic processsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of myotube differentiationsearch cellular response to lipopolysaccharidesearch regulation of transcription from RNA polymerase II promotersearch intracellular signal transductionsearch positive regulation of myoblast differentiationsearch positive regulation of myoblast fusionsearch regulation of transcription, DNA-templatedsearch signal transduction in response to DNA damagesearch fatty acid oxidationsearch glucose metabolic processsearch response to muramyl dipeptidesearch lipopolysaccharide-mediated signaling pathwaysearch transcription, DNA-templatedsearch cell morphogenesissearch cartilage condensationsearch positive regulation of transcription from RNA polymerase II promotersearch striated muscle cell differentiationsearch positive regulation of protein import into nucleussearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch angiogenesissearch response to stresssearch apoptotic processsearch p38MAPK cascadesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch