2ghl Summary


Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743

The structure was published by Brugel, T.A., Maier, J.A., Clark, M.P., et al., Hsieh, L.C., Mekel, M.J., and Janusz, M.J., in 2006 in a paper entitled "Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.099 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 333 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (5-352) (MK14_MOUSE)search Mus musculussearch 97% 348 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (5 - 352) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P47811) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P47811) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch MAP kinase activitysearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch transferase activitysearch protein phosphorylationsearch chondrocyte differentiationsearch cellular response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of myotube differentiationsearch apoptotic processsearch DNA damage checkpointsearch skeletal muscle tissue developmentsearch vascular endothelial growth factor receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch osteoclast differentiationsearch positive regulation of myoblast differentiationsearch intracellular signal transductionsearch positive regulation of myoblast fusionsearch lipopolysaccharide-mediated signaling pathwaysearch glucose metabolic processsearch response to muramyl dipeptidesearch fatty acid oxidationsearch response to stresssearch peptidyl-serine phosphorylationsearch cell morphogenesissearch cartilage condensationsearch positive regulation of protein import into nucleussearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription, DNA-templatedsearch p38MAPK cascadesearch positive regulation of brown fat cell differentiationsearch stress-induced premature senescencesearch angiogenesissearch cellular response to DNA damage stimulussearch response to lipopolysaccharidesearch positive regulation of erythrocyte differentiationsearch striated muscle cell differentiationsearch cellular response to ionizing radiationsearch positive regulation of reactive oxygen species metabolic processsearch transcription, DNA-templatedsearch cellular response to vascular endothelial growth factor stimulussearch phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch signal transduction in response to DNA damagesearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch cytosolsearch spindle polesearch cellsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch