h-CHK1 complexed with A431994
The structure was published by Zhu, G.D., Gandhi, V.B., Gong, J., et al., Li, Q., Rosenberg, S.H., and Giranda, V.L., in 2006 in a paper entitled "Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2006.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 269 residues which is < 90% of the natural sequence. Out of 269 residues 269 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: