2gh5 Summary details

pdbe.org/2gh5/summary_details
spacer Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.7 Å, R-factor: 22.41%, Free R-factor: 25.6%, Spacegroup: P 1 21 1
Released 26/09/2006, deposition: 25/03/2006, last revision: 13/07/2011
Authors Fritz-Wolf, K.search; Winzer, A.search; Bauer, H.search; Schirmer, H.search; Davioud-Charvet, E.search
Primary citation A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme
J.AM.CHEM.SOC.search vol:128, pag:10784-10794 (2006) [PubMed 16910673 ]search
Keywords human glutathione reductase; A Fluoro-Analogue of the Menadione Derivative M5search, OXIDOREDUCTASEsearch
EC 1.8.1.7 ExPASy BRENDA search (B A)
Organism Homo sapiens(human) 9606search(A B)
UniProt P00390search (A B)
Solvent A, B
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B glutathione reductase, mitochondrial Protein P00390 (GSHR_HUMAN)search
478 96%
Heterogens
Chain Id Name Ligands
A, B PHOSPHATE ION PO4 search
A, B 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID ELI search
A, B FLAVIN-ADENINE DINUCLEOTIDE FAD search
B, A GLYCEROL GOL search
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