2gfs Summary


P38 Kinase Crystal Structure in complex with RO3201195

The structure was published by Goldstein, D.M., Alfredson, T.A., Bertrand, J., et al., Whiteley, P.E., Young, K., and Zipfel, S., in 2006 in a paper entitled "Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]-methanone (RO3201195), and Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.752 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-Activated Protein Kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-Activated Protein Kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-Activated Protein Kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q16539) cytosolsearch nucleoplasmsearch cellsearch cytoplasmsearch nucleussearch spindle polesearch extracellular vesicular exosomesearch mitochondrionsearch peptidyl-serine phosphorylationsearch stress-activated MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of myotube differentiationsearch chondrocyte differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch signal transductionsearch RNA metabolic processsearch positive regulation of myoblast fusionsearch cellular response to DNA damage stimulussearch positive regulation of myoblast differentiationsearch toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch angiogenesissearch protein phosphorylationsearch phosphorylationsearch regulation of transcription from RNA polymerase II promotersearch fatty acid oxidationsearch blood coagulationsearch chemotaxissearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch regulation of transcription, DNA-templatedsearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of erythrocyte differentiationsearch response to muramyl dipeptidesearch Ras protein signal transductionsearch osteoclast differentiationsearch mRNA metabolic processsearch myoblast differentiation involved in skeletal muscle regenerationsearch lipopolysaccharide-mediated signaling pathwaysearch cellular component movementsearch 3'-UTR-mediated mRNA stabilizationsearch response to lipopolysaccharidesearch innate immune responsesearch transcription, DNA-templatedsearch positive regulation of blood vessel endothelial cell migrationsearch DNA damage checkpointsearch intracellular signal transductionsearch cartilage condensationsearch toll-like receptor 5 signaling pathwaysearch apoptotic processsearch skeletal muscle tissue developmentsearch cellular response to vascular endothelial growth factor stimulussearch glucose metabolic processsearch cellular response to ionizing radiationsearch cell morphogenesissearch toll-like receptor 10 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch striated muscle cell differentiationsearch activation of MAPK activitysearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 9 signaling pathwaysearch p38MAPK cascadesearch neurotrophin TRK receptor signaling pathwaysearch platelet activationsearch signal transduction in response to DNA damagesearch MyD88-dependent toll-like receptor signaling pathwaysearch gene expressionsearch response to stresssearch cellular response to lipopolysaccharidesearch toll-like receptor 3 signaling pathwaysearch muscle cell differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch stress-induced premature senescencesearch protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase activitysearch kinase activitysearch nucleotide bindingsearch ATP bindingsearch protein kinase activitysearch transferase activitysearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch