2ge9 Summary

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Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase

The structure was published by Huang, K.-C., Cheng, H.-T., Pai, M.-T., Tzeng, S.-R., and Cheng, J.-W., in 2006 in a paper entitled "Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase BTK. This molecule has the UniProt identifier Q06187 (BTK_HUMAN)search. The sample contained 125 residues which is < 90% of the natural sequence. Out of 125 residues 118 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase BTK Q06187 (270-387) (BTK_HUMAN)search Homo sapienssearch < 90% 125 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q06187 (270 - 387) Tyrosine-protein kinase BTK Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A SH2 domainsearch