› 2ge9

Solution NMR

Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase

Released:
DOI: 10.2210/pdb2ge9/pdb
PDB entry 2ge9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ge9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ge9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase.
Huang KC, Cheng HT, Pai MT, Tzeng SR, Cheng JW
J Biomol NMR 36 73-8 (2006)
PMID: 16969585

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06187 (Residues: 269-387; Coverage: 18%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The Src, Syk, and Tec family kinases: distinct types of molecular switches.
Bradshaw JM. (2010)
1 more

8 mentions without citation

The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.
Crofford et al. (2016)
7 more