4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors
The structure was published by Ni, Z.J., Barsanti, P., Brammeier, N., et al., Jansen, J.M., Ma, S., and Gesner, T.G., in 2006 in a paper entitled "4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2006.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 295 residues which is < 90% of the natural sequence. Out of 295 residues 268 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: