2gd8 Summary


Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate

The structure was published by Leese, M.P., Leblond, B., Smith, A., et al., Purohit, A., Reed, M.J., and Potter, B.V., in 2006 in a paper entitled "2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.46 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 99% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-259) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 259) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch response to organic substancesearch response to estrogensearch morphogenesis of an epitheliumsearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch secretionsearch response to zinc ionsearch response to steroid hormonesearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch kidney developmentsearch response to pHsearch positive regulation of osteoclast differentiationsearch small molecule metabolic processsearch positive regulation of bone resorptionsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch plasma membranesearch cytosolsearch cytoplasmsearch axonsearch membranesearch myelin sheathsearch basolateral plasma membranesearch apical part of cellsearch extracellular spacesearch extracellular vesicular exosomesearch microvillussearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch