Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133210 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Factor X light chain
Molecule details ›
Chains: A, L
Length: 58 amino acids
Theoretical weight: 6.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
Length: 58 amino acids
Theoretical weight: 6.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P00742 (Residues: 125-182; Coverage: 13%)
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
Activated factor Xa heavy chain
Molecule details ›
Chains: B, H
Length: 241 amino acids
Theoretical weight: 27.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 241 amino acids
Theoretical weight: 27.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P00742 (Residues: 235-475; Coverage: 53%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Antithrombin-III
Molecule details ›
Chains: C, I
Length: 443 amino acids
Theoretical weight: 50.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Length: 443 amino acids
Theoretical weight: 50.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01008 (Residues: 22-464; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
SRS BEAMLINE PX14.1
Spacegroup:
C2
Expression systems:
- Escherichia coli
- Not provided
