2gcd Summary

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TAO2 kinase domain-staurosporine structure

The structure was published by Zhou, T.J., Sun, L.G., Gao, Y., and Goldsmith, E.J., in 2006 in a paper entitled "Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase TAO2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase TAO2 Q9JLS3 (12-320) (TAOK2_RAT)search Rattus norvegicussearch < 90% 309 100%
B Serine/threonine-protein kinase TAO2 Q9JLS3 (12-320) (TAOK2_RAT)search Rattus norvegicussearch < 90% 309 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9JLS3 (12 - 320) Serine/threonine-protein kinase TAO2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q9JLS3) protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch