2g9x Summary


Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271

The structure was published by Griffin, R.J., Henderson, A., Curtin, N.J., et al., Noble, M.E., Wang, L.Z., and Golding, B.T., in 2006 in a paper entitled "Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cell division protein kinase 2 and Cyclin-A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 100%
C Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 100%
B Cyclin-A2 P30274 (170-430) (CCNA2_BOVIN)search Bos taurussearch < 90% 262 100%
D Cyclin-A2 P30274 (170-430) (CCNA2_BOVIN)search Bos taurussearch < 90% 262 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens
P30274 (170 - 430) Cyclin-A2 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein bindingsearch nucleotide bindingsearch cyclin bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch kinase activitysearch histone kinase activitysearch metal ion bindingsearch protein serine/threonine kinase activitysearch potassium ion transportsearch blood coagulationsearch centrosome duplicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic G1 DNA damage checkpointsearch protein phosphorylationsearch mitotic nuclear divisionsearch positive regulation of cell proliferationsearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch phosphorylationsearch meiotic nuclear divisionsearch regulation of gene silencingsearch G2/M transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch histone phosphorylationsearch DNA repairsearch cell cyclesearch cellular response to nitric oxidesearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to DNA damage stimulussearch nucleoplasmsearch Y chromosomesearch nucleussearch Cajal bodysearch transcription factor complexsearch chromosome, telomeric regionsearch cytoskeletonsearch endosomesearch microtubule organizing centersearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch condensed chromosomesearch centrosomesearch X chromosomesearch
B, D (P30274) protein kinase bindingsearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch