Structure analysis

Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271

X-ray diffraction
2.5Å resolution
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 23587.5 Å2
Buried surface area: 4575.85 Å2
Dissociation area: 1,809.83 Å2
Dissociation energy (ΔGdiss): 16.67 kcal/mol
Dissociation entropy (TΔSdiss): 13.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150314
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 22708.93 Å2
Buried surface area: 4653.28 Å2
Dissociation area: 1,845.18 Å2
Dissociation energy (ΔGdiss): 15.18 kcal/mol
Dissociation entropy (TΔSdiss): 13.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150314

Macromolecules

Chains: A, C
Length: 299 amino acids
Theoretical weight: 34.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit

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Chains: B, D
Length: 262 amino acids
Theoretical weight: 30 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P30274 (Residues: 170-430; Coverage: 61%)
Gene name: CCNA2
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin

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