2g9h Summary

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Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule

The structure was published by Fernandez, M.M., Guan, R., Swaminathan, C.P., Malchiodi, E.L., and Mariuzza, R.A., in 2006 in a paper entitled "Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This entry contains 16 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-207) (DRA_HUMAN)search Homo sapienssearch < 90% 182 97%
B HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 100%
C Hemagglutinin P04664 (306-318) (HEMA_I69A0)search Influenza A virus (A/England/878/1969(H3N2))search < 90% 13 100%
D extracellular enterotoxin type I Q52T95 (1-218) (Q52T95_STAAU)search Staphylococcus aureussearch 100% 218 97%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 207) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P04229 (30 - 219) HLA class II histocompatibility antigen, DRB1-1 beta chain Homo sapiens
P04664 (306 - 318) Hemagglutinin
Q52T95 (1 - 218) extracellular enterotoxin type I Staphylococcus aureus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C Haemagglutininsearch
D (Q52T95) Superantigen toxins, N-terminal domainsearch, Superantigen toxins, C-terminal domainsearch Ubiquitin-like (UB roll)search PF01123: Staphylococcal/Streptococcal toxin, OB-fold domainsearch, PF02876: Staphylococcal/Streptococcal toxin, beta-grasp domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P01903) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch
B (P04229) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch
D (Q52T95) pathogenesissearch extracellular regionsearch metal ion bindingsearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C
D Staphylococcal/Streptococcal toxin, beta-grasp domainsearch Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved sitesearch Staphylococcal/Streptococcal toxin, OB-foldsearch Enterotoxinsearch Superantigen, staphylococcal/streptococcal toxin, bacterialsearch Superantigen toxin, C-terminalsearch