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PDBe Entry: 2g70 
Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)
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TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 2.4 Å, R-factor: 24.0%, Free R-factor: 28.5%, Spacegroup: P 43 21 2
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13/02/2007, deposition: 27/02/2006, last revision: 24/02/2009
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Tyndall, J.D.A.; Gee, C.L.; Martin, J.L.
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Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
J.MED.CHEM. vol:50, pag:4845-4853 (2007) [PubMed ID 17845018 ]
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methyltransferase
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2.1.1.28 ExPASy BRENDA (A B)
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Homo sapiens(human) 9606(A B)
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Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase) P11086 (A B)
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A, B
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1hnn, 1nji, 1n7j, 1yz3, 2an3, 2an4, 2g71, 2g72
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| A, B |
Phenylethanolamine N-methyltransferase |
Protein |
P11086 (PNMT_HUMAN)
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289 |
91% |
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| B |
PHOSPHATE ION |
PO4
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| A, B |
S-ADENOSYLMETHIONINE |
SAM
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| A, B |
[(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL |
HNT
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