› 2g64

X-ray diffraction
1.8Å resolution

Structure of Caenorhabditis elegans 6-pyruvoyl tetrahydropterin synthase

Released:
DOI: 10.2210/pdb2g64/pdb
PDB entry 2g64 coloured by chain, front view.
PDB entry 2g64 coloured by chain, side view.
PDB entry 2g64 coloured by chain, top view.
Source organism: Caenorhabditis elegans
Entry authors: Wengerter BC, Patskovsky Y, Zhan C, Ramagopal U, Milstein S, Vidal M, Almo SC, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126413 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative 6-pyruvoyl tetrahydrobiopterin synthase Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.06 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: O02058 (Residues: 1-140; Coverage: 100%)
Gene names: B0041.6, ptps-1
Sequence domains: 6-pyruvoyl tetrahydropterin synthase
Structure domains: 6-pyruvoyl tetrahydropterin synthase/QueD

Ligands and Environments

3 bound ligands:
Ligand NA 2 x NA
Ligand ZN 1 x ZN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: R32
Unit cell:
a: 69.792Å b: 69.792Å c: 160.188Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.161 0.219
Expression system: Escherichia coli

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