2g5o Summary


Human estrogen receptor alpha ligand-binding domain in complex with 2-(but-1-enyl)-17beta-estradiol and a glucocorticoid receptor interacting protein 1 NR BOX II Peptide

A publication describing this structure is not available. The depositing authors are Rajan, S.S.search; Hsieh, R.W.search; Sharma, S.K.search; Greene, G.L.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 257 92%
B Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 257 92%
C Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 76%
D Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 76%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (298 - 554) Estrogen receptor Homo sapiens
Q15596 (686 - 698) Nuclear receptor coactivator 2

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch
C, D Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P03372) steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search