2g41 Summary


Crystal structure of the complex of sheep signalling glycoprotein with chitin trimer at 3.0A resolution

The structure was published by Srivastava, D.B., Ethayathulla, A.S., Kumar, J., et al., Sharma, S., Dey, S., and Singh, T.P., in 2007 in a paper entitled "Carbohydrate binding properties and carbohydrate induced conformational switch in sheep secretory glycoprotein (SPS-40): crystal structures of four complexes of SPS-40 with chitin-like oligosaccharides" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of SIGNAL PROCESSING PROTEIN. This molecule has the UniProt identifier Q6TMG6 (CH3L1_SHEEP)search. The sample contained 361 residues which is 100% of the natural sequence. Out of 361 residues 361 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SIGNAL PROCESSING PROTEIN Q6TMG6 (1-361) (CH3L1_SHEEP)search Ovis ariessearch 100% 361 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q6TMG6) Type II chitinasesearch, Chitinase insertion domainsearch Glycosidasessearch, Chitinase A; domain 3search PF00704: Glycosyl hydrolases family 18search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q6TMG6) extracellular spacesearch endoplasmic reticulumsearch cytoplasmsearch perinuclear region of cytoplasmsearch extracellular regionsearch chitin bindingsearch chitinase activitysearch hydrolase activity, hydrolyzing O-glycosyl compoundssearch carbohydrate bindingsearch positive regulation of angiogenesissearch carbohydrate metabolic processsearch response to tumor necrosis factorsearch response to interleukin-1search positive regulation of protein kinase B signalingsearch chitin catabolic processsearch positive regulation of ERK1 and ERK2 cascadesearch response to mechanical stimulussearch apoptotic processsearch activation of NF-kappaB-inducing kinase activitysearch interleukin-8 secretionsearch inflammatory responsesearch cellular response to tumor necrosis factorsearch positive regulation of peptidyl-threonine phosphorylationsearch lung developmentsearch response to interleukin-6search

Chain InterPro annotation
A Glycoside hydrolase, family 18, catalytic domainsearch Chitinase IIsearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase superfamilysearch Chitinase-3-like protein 1search Chitinase insertion domainsearch