2g1t Summary

pdbe.org/2g1t
spacer

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

The structure was published by Levinson, N.M., Kuchment, O., Shen, K., et al., Karplus, M., Cole, P.A., and Kuriyan, J., in 2006 in a paper entitled "A SRC-like inactive conformation in the abl tyrosine kinase domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Proto-oncogene tyrosine-protein kinase ABL1 and ATP-Peptide Conjugate.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00519 (229-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 287 96%
B Proto-oncogene tyrosine-protein kinase ABL1 P00519 (229-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 287 96%
C Proto-oncogene tyrosine-protein kinase ABL1 P00519 (229-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 287 96%
D Proto-oncogene tyrosine-protein kinase ABL1 P00519 (229-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 287 96%
E ATP-Peptide Conjugate Not available
Synthetic Not available 13 76%
F ATP-Peptide Conjugate Not available
Synthetic Not available 13 76%
G ATP-Peptide Conjugate Not available
Synthetic Not available 13 76%
H ATP-Peptide Conjugate Not available
Synthetic Not available 13 76%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (229 - 512) Proto-oncogene tyrosine-protein kinase ABL1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
E, F, G, H

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (P00519) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
E, F, G, H