Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
The structure was published by Liu, M., Xin, Z., Clampit, J.E., et al., Fry, E.H., Sham, H.L., and Liu, G., in 2006 in a paper entitled "Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2006.
The experimental data on which the structure is based was not deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely Mitogen-activated protein kinase 8 and C-jun-amino-terminal kinase-interacting protein 1.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: