2fye Summary

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Mutant Human Cathepsin S with irreversible inhibitor CRA-14013

A publication describing this structure is not available. The depositing authors are Somoza, J.R.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of cathepsin S preproprotein. This molecule has the UniProt identifier P25774 (CATS_HUMAN)search. The sample contained 217 residues which is < 90% of the natural sequence. Out of 217 residues 211 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cathepsin S preproprotein P25774 (115-331) (CATS_HUMAN)search Homo sapienssearch 100% 217 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P25774 (115 - 331) cathepsin S preproprotein Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P25774) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P25774) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch