2fw4 Summary


Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.

The structure was published by Temperini, C., Scozzafava, A., and Supuran, C.T., in 2006 in a paper entitled "Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carbonic anhydrase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 1 P00915 (2-261) (CAH1_HUMAN)search Homo sapienssearch 98% 260 98%
B Carbonic anhydrase 1 P00915 (2-261) (CAH1_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00915 (2 - 261) Carbonic anhydrase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00915) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P00915) carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch cytoplasmsearch cytosolsearch extracellular vesicular exosomesearch one-carbon metabolic processsearch bicarbonate transportsearch small molecule metabolic processsearch

Chain InterPro annotation
A, B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA1search Carbonic anhydrase, alpha-classsearch