2fvj Summary


A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro

The structure was published by Burgermeister, E., Schnoebelen, A., Flament, A., et al., Sebokova, E., Niesor, E., and Meyer, M., in 2006 in a paper entitled "A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.99 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Peroxisome proliferator-activated receptor gamma and Nuclear receptor coactivator 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor gamma P37231 (235-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 271 95%
B Nuclear receptor coactivator 1 Q15788 (628-640) (NCOA1_HUMAN)search Homo sapienssearch < 90% 13 76%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P37231 (235 - 505) Peroxisome proliferator-activated receptor gamma Homo sapiens
Q15788 (628 - 640) Nuclear receptor coactivator 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P37231) ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch
B (Q15788) histone acetyltransferase activitysearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear receptor coactivator Src-1search