2fsz Summary

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A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta

The structure was published by Wang, Y., Chirgadze, N.Y., Briggs, S.L., Khan, S., Jensen, E.V., and Burris, T.P., in 2006 in a paper entitled "A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen receptor beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor beta Q92731 (257-502) (ESR2_HUMAN)search Homo sapienssearch < 90% 246 92%
B Estrogen receptor beta Q92731 (257-502) (ESR2_HUMAN)search Homo sapienssearch < 90% 246 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q92731 (257 - 502) Estrogen receptor beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q92731) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch