2fst Summary


mitogen activated protein kinase p38alpha (D176A+F327L) activating mutant

The structure was published by Diskin, R., Lebendiker, M., Engelberg, D., and Livnah, O., in 2007 in a paper entitled "Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 367 residues which is 100% of the natural sequence. Out of 367 residues 324 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 367 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
X (Q16539) MyD88-dependent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch gene expressionsearch cellular response to DNA damage stimulussearch mRNA metabolic processsearch cellular response to ionizing radiationsearch positive regulation of myoblast fusionsearch skeletal muscle tissue developmentsearch toll-like receptor 3 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch protein phosphorylationsearch DNA damage checkpointsearch glucose metabolic processsearch intracellular signal transductionsearch toll-like receptor 2 signaling pathwaysearch Ras protein signal transductionsearch cellular component movementsearch apoptotic processsearch toll-like receptor 4 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to lipopolysaccharidesearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription from RNA polymerase II promotersearch muscle cell differentiationsearch innate immune responsesearch lipopolysaccharide-mediated signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch negative regulation of canonical Wnt signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of protein import into nucleussearch chondrocyte differentiationsearch positive regulation of myotube differentiationsearch osteoclast differentiationsearch fatty acid oxidationsearch regulation of transcription, DNA-templatedsearch phosphorylationsearch vascular endothelial growth factor receptor signaling pathwaysearch p38MAPK cascadesearch chemotaxissearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cell morphogenesissearch RNA metabolic processsearch striated muscle cell differentiationsearch positive regulation of erythrocyte differentiationsearch platelet activationsearch signal transductionsearch toll-like receptor 5 signaling pathwaysearch activation of MAPK activitysearch toll-like receptor 10 signaling pathwaysearch response to lipopolysaccharidesearch positive regulation of muscle cell differentiationsearch response to muramyl dipeptidesearch toll-like receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myoblast differentiationsearch blood coagulationsearch cell surface receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch angiogenesissearch peptidyl-serine phosphorylationsearch stress-induced premature senescencesearch cartilage condensationsearch signal transduction in response to DNA damagesearch response to stresssearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch transcription, DNA-templatedsearch protein bindingsearch kinase activitysearch transferase activitysearch nucleotide bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch MAP kinase kinase activitysearch nucleussearch nucleoplasmsearch spindle polesearch mitochondrionsearch extracellular vesicular exosomesearch cytosolsearch cytoplasmsearch cellsearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch