2fsl Summary


mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-A

The structure was published by Diskin, R., Lebendiker, M., Engelberg, D., and Livnah, O., in 2007 in a paper entitled "Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 367 residues which is 100% of the natural sequence. Out of 367 residues 331 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 367 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
X (Q16539) protein phosphorylationsearch cell morphogenesissearch toll-like receptor 2 signaling pathwaysearch signal transductionsearch positive regulation of muscle cell differentiationsearch angiogenesissearch MyD88-dependent toll-like receptor signaling pathwaysearch cellular response to DNA damage stimulussearch positive regulation of myoblast differentiationsearch movement of cell or subcellular componentsearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch myoblast differentiation involved in skeletal muscle regenerationsearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor TLR1:TLR2 signaling pathwaysearch apoptotic processsearch positive regulation of protein import into nucleussearch regulation of transcription, DNA-templatedsearch stress-induced premature senescencesearch muscle cell differentiationsearch osteoclast differentiationsearch striated muscle cell differentiationsearch response to lipopolysaccharidesearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch regulation of cytokine production involved in inflammatory responsesearch transcription, DNA-templatedsearch chondrocyte differentiationsearch toll-like receptor 4 signaling pathwaysearch signal transduction in response to DNA damagesearch gene expressionsearch peptidyl-serine phosphorylationsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myotube differentiationsearch chemotaxissearch cartilage condensationsearch skeletal muscle tissue developmentsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cellular response to lipopolysaccharidesearch activation of MAPK activitysearch toll-like receptor 10 signaling pathwaysearch organelle organizationsearch stress-activated MAPK cascadesearch 3'-UTR-mediated mRNA stabilizationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch Ras protein signal transductionsearch toll-like receptor 3 signaling pathwaysearch innate immune responsesearch platelet activationsearch positive regulation of myoblast fusionsearch toll-like receptor 9 signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch intracellular signal transductionsearch blood coagulationsearch p38MAPK cascadesearch positive regulation of transcription from RNA polymerase II promotersearch fatty acid oxidationsearch phosphorylationsearch cell surface receptor signaling pathwaysearch DNA damage checkpointsearch lipopolysaccharide-mediated signaling pathwaysearch mitochondrion organizationsearch positive regulation of brown fat cell differentiationsearch positive regulation of cyclase activitysearch toll-like receptor 5 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch cellular response to ionizing radiationsearch glucose metabolic processsearch response to muramyl dipeptidesearch positive regulation of blood vessel endothelial cell migrationsearch ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch protein bindingsearch NFAT protein bindingsearch transferase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch cytoplasmsearch nucleoplasmsearch cellsearch cytosolsearch nucleussearch extracellular exosomesearch mitochondrionsearch spindle polesearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch