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EBI PDBe PDBeView

PDBe Entry: 2fpt view

Dual Binding Mode of a Novel Series of DHODH inhibitors
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.4 Å, R-factor: 17.5%, Free R-factor: 21.1%, Spacegroup: P 32 2 1
Released 23/01/2007, deposition: 17/01/2006, last revision: 24/02/2009
Authors Baumgartner, R.search; Walloschek, M.search; Kralik, M.search; Gotschlich, A.search; Tasler, S.search; Leban, J.search
Primary citation Dual binding mode of a novel series of DHODH inhibitors.
J.MED.CHEM.search vol:49, pag:1239-1247 (2006) [PubMed ID 16480261 ]search
Keywords protein inhibitor complexsearch, OXIDOREDUCTASEsearch
EC 1.3.5.2 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (DHOdehase) (Dihydroorotate oxidase) Q02127search (A)
Solvent A
Related entries 2bxv, 2fpv, 2fpy
Polymers
Id Name Type UniProt Residues Observed
A Dihydroorotate dehydrogenase, mitochondrial Protein Q02127 (PYRD_HUMAN)search
 395 92%
Heterogens
Id Name Ligands
A SULFATE ION SO4 search
A ACETATE ION ACT search
A FLAVIN MONONUCLEOTIDE FMN search
A OROTIC ACID ORO search
A 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID ILB search
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