2fou Summary


Human Carbonic Anhydrase II complexed with two-prong inhibitors

The structure was published by Jude, K.M., Banerjee, A.L., Haldar, M.K., et al., Mallik, S., Srivastava, D.K., and Christianson, D.W., in 2006 in a paper entitled "Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 0.99 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic Anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 259 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase II P00918 (1-259) (CAH2_HUMAN)search Homo sapienssearch 98% 260 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 259) Carbonic Anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch one-carbon metabolic processsearch response to zinc ionsearch response to pHsearch odontogenesis of dentin-containing toothsearch bicarbonate transportsearch regulation of anion transportsearch response to estrogensearch morphogenesis of an epitheliumsearch regulation of intracellular pHsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch response to organic substancesearch small molecule metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch secretionsearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch extracellular vesicular exosomesearch apical part of cellsearch microvillussearch cytoplasmsearch cytosolsearch membranesearch plasma membranesearch extracellular spacesearch axonsearch basolateral plasma membranesearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch