2fo1 Summary

pdbe.org/2fo1
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Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA

The structure was published by Wilson, J.J. and Kovall, R.A., in 2006 in a paper entitled "Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This entry contains 5 copies of 5 unique biopolymers (complete list).

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Lin-12 and glp-1 phenotype protein 1, isoform b Q8MXE7 (190-661) (Q8MXE7_CAEEL)search Caenorhabditis eleganssearch < 90% 477 92%
D Protein lag-3 Q09260 (49-132) (LAG3_CAEEL)search Caenorhabditis eleganssearch < 90% 85 74%
E Lin-12 protein P14585 (931-1301) (LIN12_CAEEL)search Caenorhabditis eleganssearch < 90% 373 79%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8MXE7 (190 - 661) Lin-12 and glp-1 phenotype protein 1, isoform b Caenorhabditis elegans
Q09260 (49 - 132) Protein lag-3 Caenorhabditis elegans
P14585 (931 - 1301) Lin-12 protein Caenorhabditis elegans

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A NF-kappa-B/REL/DORSAL transcription factors, C-terminal domainsearch, DNA-binding protein LAG-1 (CSL)search Lin-12 and glp-1 transcriptional regulator; domain 1search, Trefoil (Acidic Fibroblast Growth Factor, subunit A)search, Immunoglobulinssearch Beta-trefoil DNA-binding domainsearch, LAG1, DNA bindingsearch
D Lag-3 N-terminal regionsearch Transcriptional activator LAG-3search
E Ankyrin repeatsearch Ankyrin repeatsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q8MXE7) nucleussearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitysearch RNA polymerase II core promoter proximal region sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A IPT domainsearch p53-like transcription factor, DNA-bindingsearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch Beta-trefoil DNA-binding domainsearch LAG1, DNA bindingsearch
D Transcription activator LAG-3search
E Ankyrin repeatsearch Ankyrin repeat-containing domainsearch