2fo0 Summary details

pdbe.org/2fo0/summary_details
spacer Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.27 Å, R-factor: 21.0%, Free R-factor: 24.6%, Spacegroup: P 21 21 2
Released 21/03/2006, deposition: 12/01/2006, last revision: 13/07/2011
Authors Nagar, B.search; Hantschel, O.search; Seeliger, M.search; Davies, J.M.search; Weis, W.I.search; Superti-Furga, G.search; Kuriyan, J.search
Primary citation Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
MOL.CELLsearch vol:21, pag:787-798 (2006) [PubMed 16543148 ]search
Keywords N-terminal capsearch, autoinhibitionsearch, myristoylationsearch, SH3-SH2 clampsearch, phosphoserinesearch, TRANSFERASEsearch
EC 2.7.10.2 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt P00519search (A)
Solvent A
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A Proto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM) Protein P00519 (ABL1_HUMAN)search
495 94%
Heterogens
Chain Id Name Ligands
A MYRISTIC ACID MYR search
A 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE P16 search
A GLYCEROL GOL search
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