Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
The structure was published by Nagar, B., Hantschel, O., Seeliger, M., et al., Weis, W.I., Superti-Furga, G., and Kuriyan, J., in 2006 in a paper entitled "Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.27 Å and deposited in 2006.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM). This molecule has the UniProt identifier P00519 (ABL1_HUMAN). The sample contained 495 residues which is < 90% of the natural sequence. Out of 495 residues 466 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: