spacer Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
SCOP: Structural Classification of Proteins
Domain 133862search
SCCS b.34.2.1search
Description 2fo0 A:76-138
Comments automatically matched to d2abl_1
complexed with gol, myr, p16; mutant
Polymers A
Hierarchy
Class All beta proteins search
Fold SH3-like barrel search
barrel, partly opened; n*=4, S*=8; meander
the last strand is interrupted by a turn of 3-10 helix
Superfamily SH3-domain search
Family SH3-domain search
Protein Abl tyrosine kinase, SH3 domain search
 
Domain 133863search
SCCS d.93.1.1search
Description 2fo0 A:139-239
Comments automatically matched to d1ab2__
complexed with gol, myr, p16; mutant
Polymers A
Hierarchy
Class Alpha and beta proteins (a+b) search
Fold SH2-like search
3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
Superfamily SH2 domain search
Family SH2 domain search
Pfam 00017
Protein Proto-oncogen tyrosine kinase search
 
Domain 133864search
SCCS d.144.1.7search
Description 2fo0 A:241-530
Comments automatically matched to d1opla3
complexed with gol, myr, p16; mutant
Polymers A
Hierarchy
Class Alpha and beta proteins (a+b) search
Fold Protein kinase-like (PK-like) search
consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
Superfamily Protein kinase-like (PK-like) search
shares functional and structural similarities with the ATP-grasp fold and PIPK
Family Protein kinases, catalytic subunit search
members organized in the groups and subfamiles specified by the comments
Protein Abelsone tyrosine kinase (abl) search
PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
 
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