2fnn Summary


Activation of human carbonic anhydrase II by exogenous proton donors

The structure was published by Bhatt, D., Fisher, S.Z., Tu, C., McKenna, R., and Silverman, D.N., in 2007 in a paper entitled "Location of binding sites in small molecule rescue of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic Anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic Anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) one-carbon metabolic processsearch response to organic substancesearch morphogenesis of an epitheliumsearch bicarbonate transportsearch regulation of anion transportsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch carbon dioxide transportsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch secretionsearch response to estrogensearch regulation of intracellular pHsearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch small molecule metabolic processsearch kidney developmentsearch angiotensin-activated signaling pathwaysearch basolateral plasma membranesearch cytosolsearch axonsearch extracellular vesicular exosomesearch extracellular spacesearch plasma membranesearch apical part of cellsearch membranesearch cytoplasmsearch microvillussearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch