2fnn Summary

pdbe.org/2fnn
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Activation of human carbonic anhydrase II by exogenous proton donors

The structure was published by Bhatt, D., Fisher, S.Z., Tu, C., McKenna, R., and Silverman, D.N., in 2007 in a paper entitled "Location of binding sites in small molecule rescue of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic Anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic Anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch small molecule metabolic processsearch response to organic substancesearch response to estrogensearch one-carbon metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch bicarbonate transportsearch positive regulation of cellular pH reductionsearch secretionsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch regulation of intracellular pHsearch regulation of anion transportsearch response to steroid hormonesearch response to pHsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch lyase activitysearch protein bindingsearch basolateral plasma membranesearch cytoplasmsearch cytosolsearch apical part of cellsearch extracellular spacesearch axonsearch extracellular vesicular exosomesearch plasma membranesearch microvillussearch membranesearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch