2fnm Summary


Activation of human carbonic anhdyrase II by exogenous proton donors

The structure was published by Bhatt, D., Fisher, S.Z., Tu, C., McKenna, R., and Silverman, D.N., in 2007 in a paper entitled "Location of binding sites in small molecule rescue of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch lyase activitysearch one-carbon metabolic processsearch regulation of anion transportsearch kidney developmentsearch response to organic substancesearch bicarbonate transportsearch secretionsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch regulation of intracellular pHsearch response to zinc ionsearch small molecule metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch response to pHsearch response to estrogensearch positive regulation of osteoclast differentiationsearch extracellular vesicular exosomesearch axonsearch microvillussearch cytosolsearch plasma membranesearch cytoplasmsearch apical part of cellsearch myelin sheathsearch basolateral plasma membranesearch extracellular spacesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch