Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887
The structure was published by Pejchal, R., Campbell, E., Guenther, B.D., Lennon, B.W., Matthews, R.G., and Ludwig, M.L., in 2006 in a paper entitled "Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2006.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of 5,10-methylenetetrahydrofolate reductase.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homotetramers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: