2fmn Summary

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Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887

The structure was published by Pejchal, R., Campbell, E., Guenther, B.D., Lennon, B.W., Matthews, R.G., and Ludwig, M.L., in 2006 in a paper entitled "Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 5,10-methylenetetrahydrofolate reductase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 5,10-methylenetetrahydrofolate reductase P0AEZ1 (1-296) (METF_ECOLI)search Escherichia coli K-12search 93% 304 94%
B 5,10-methylenetetrahydrofolate reductase P0AEZ1 (1-296) (METF_ECOLI)search Escherichia coli K-12search 93% 304 94%
C 5,10-methylenetetrahydrofolate reductase P0AEZ1 (1-296) (METF_ECOLI)search Escherichia coli K-12search 93% 304 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0AEZ1 (1 - 296) 5,10-methylenetetrahydrofolate reductase Escherichia coli

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C (P0AEZ1) TIM Barrelsearch PF02219: Methylenetetrahydrofolate reductasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C (P0AEZ1) oxidation-reduction processsearch methionine metabolic processsearch methionine biosynthetic processsearch tetrahydrofolate interconversionsearch cellular amino acid biosynthetic processsearch methylenetetrahydrofolate reductase (NAD(P)H) activitysearch oxidoreductase activitysearch cytosolsearch

Chain InterPro annotation
A, B, C Methylenetetrahydrofolate reductasesearch 5,10-methylenetetrahydrofolate reductasesearch