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EBI PDBe PDBeView

PDBe Entry: 2fmn view

Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.05 Å, R-factor: 21.7%, Free R-factor: 25.0%, Spacegroup: C 1 2 1
Released 25/04/2006, deposition: 09/01/2006, last revision: 24/02/2009
Authors Pejchal, R.search; Campbell, E.search; Guenther, B.D.search; Lennon, B.W.search; Matthews, R.G.search; Ludwig, M.L.search
Primary citation Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation
BIOCHEMISTRYsearch vol:45, pag:4808-4818 (2006) [PubMed ID 16605249 ]search
Keywords OXIDOREDUCTASEsearch, TIM BARRELsearch, FLAVINsearch, REDUCTASEsearch
EC 1.5.1.20 ExPASy BRENDA search (A B C)
Organism Escherichia coli 562search(A B C)
UniProt 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) P0AEZ1search (A B C)
Solvent A, B, C
Related entries 2fmo
Polymers
Id Name Type UniProt Residues Observed
A, B, C 5,10-methylenetetrahydrofolate reductase Protein P0AEZ1 (METF_ECOLI)search
 304 94%
Heterogens
Id Name Ligands
A, B, C FLAVIN-ADENINE DINUCLEOTIDE FAD search
A, B, C N-[(5-{2-[(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPYRIDO[2,3-D]PYRIMIDIN-6-YL]ETHYL}-2-THIENYL)CARBONYL]-L-GLUTAMIC ACID 4HF search
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