2fmg Summary


Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine

The structure was published by Temperini, C., Scozzafava, A., Vullo, D., and Supuran, C.T., in 2006 in a paper entitled "Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-259) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 259) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch kidney developmentsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch response to steroid hormonesearch regulation of intracellular pHsearch response to zinc ionsearch bicarbonate transportsearch response to organic substancesearch one-carbon metabolic processsearch response to estrogensearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch secretionsearch angiotensin-activated signaling pathwaysearch positive regulation of synaptic transmission, GABAergicsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch cytosolsearch plasma membranesearch cytoplasmsearch apical part of cellsearch membranesearch myelin sheathsearch microvillussearch extracellular vesicular exosomesearch axonsearch extracellular spacesearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch