2flb Summary

pdbe.org/2flb
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Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

The structure was published by Vijaykumar, D., Sprengeler, P.A., Shaghafi, M., et al., Young, W.B., Schultz, B., and Janc, J., in 2006 in a paper entitled "Discovery of novel hydroxy pyrazole based factor IXa inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Coagulation factor VII and Tissue factor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Coagulation factor VII P08709 (61-212) (FA7_HUMAN)search Homo sapienssearch < 90% 152 63%
H Coagulation factor VII P08709 (213-466) (FA7_HUMAN)search Homo sapienssearch < 90% 254 100%
T Tissue factor P13726 (34-251) (TF_HUMAN)search Homo sapienssearch < 90% 218 69%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P08709 (61 - 212) Coagulation factor VII Homo sapiens
P13726 (34 - 251) Tissue factor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L Lamininsearch EGF-like domainsearch, Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domainsearch
H Eukaryotic proteasessearch Trypsin-like serine proteasessearch Trypsinsearch
T Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon-alpha/beta receptor, fibronectin type IIIsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
L (P08709) calcium ion bindingsearch extracellular regionsearch
H (P08709) serine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch
T (P13726) blood coagulationsearch integral component of membranesearch

Chain InterPro annotation
L EGF-type aspartate/asparagine hydroxylation sitesearch Gamma-carboxyglutamic acid-rich (GLA) domainsearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch EGF-like, conserved sitesearch Coagulation factor, subgroup, Gla domainsearch EGF-like calcium-binding, conserved sitesearch
H Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
T Tissue factorsearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Interferon alpha/beta receptor, beta chainsearch