› 2fh1

X-ray diffraction
1.55Å resolution

C-terminal half of gelsolin soaked in low calcium at pH 4.5

Released:
DOI: 10.2210/pdb2fh1/pdb
PDB entry 2fh1 coloured by chain, front view.
PDB entry 2fh1 coloured by chain, side view.
PDB entry 2fh1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium ion exchange in crystalline gelsolin.
Chumnarnsilpa S, Loonchanta A, Xue B, Choe H, Urosev D, Wang H, Lindberg U, Burtnick LD, Robinson RC
J Mol Biol 357 773-82 (2006)
PMID: 16466744

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gelsolin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 344 amino acids
Theoretical weight: 37.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06396 (Residues: 439-782; Coverage: 46%)
Gene name: GSN
Sequence domains: Gelsolin repeat
Structure domains: Severin

Ligands and Environments

1 bound ligand:
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P212121
Unit cell:
a: 84.822Å b: 90.32Å c: 156.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.214
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Gelsolin: the tail of a molecular gymnast.
Nag et al. (2013)
10 other articles

4 mentions without citation

Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines.
LaBute et al. (2014)
3 more