› 2fgi

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074

Released:
DOI: 10.2210/pdb2fgi/pdb
PDB entry 2fgi coloured by chain, front view.
PDB entry 2fgi coloured by chain, side view.
PDB entry 2fgi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
Mohammadi M, Froum S, Hamby JM, Schroeder MC, Panek RL, Lu GH, Eliseenkova AV, Green D, Schlessinger J, Hubbard SR
EMBO J 17 5896-904 (1998)
PMID: 9774334

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 35.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11362 (Residues: 456-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PD1 2 x PD1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 208.79Å b: 57.38Å c: 66.18Å
α: 90° β: 107.55° γ: 90°
R-values:
R R work R free
0.204 0.204 0.264
Expression system: Spodoptera frugiperda

Quick links

Citations

55 review citations

Fibroblast growth factor signalling: from development to cancer.
Turner et al. (2010)
54 more

15 mentions without citation

Developing irreversible inhibitors of the protein kinase cysteinome.
Liu et al. (2013)
14 more