2ffx Summary


Structure of Human Ferritin L. Chain

The structure was published by Wang, Z.M., Li, C., Ellenburg, M.P., et al., Wright, B.S., Ho, J.X., and Carter, D.C., in 2006 in a paper entitled "Structure of human ferritin L chain" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of ferritin light chain. This molecule has the UniProt identifier P02792 (FRIL_HUMAN)search. The sample contained 173 residues which is 99% of the natural sequence. Out of 173 residues 173 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 24meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
J ferritin light chain P02792 (2-174) (FRIL_HUMAN)search Homo sapienssearch 95% 173 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02792 (2 - 174) ferritin light chain Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
J (P02792) Ferritin;search PF00210: Ferritin-like domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
J (P02792) ferric iron bindingsearch iron ion bindingsearch protein bindingsearch identical protein bindingsearch metal ion bindingsearch cellular iron ion homeostasissearch receptor-mediated endocytosissearch transmembrane transportsearch post-Golgi vesicle-mediated transportsearch membrane organizationsearch iron ion homeostasissearch iron ion transportsearch extracellular exosomesearch membranesearch intracellular ferritin complexsearch cytosolsearch

Chain InterPro annotation
J Ferritinsearch Ferritin/DPS protein domainsearch Ferritin- like diiron domainsearch Ferritin-like superfamilysearch Ferritin-relatedsearch Ferritin, conserved sitesearch