2ff0 Summary


Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit Promoter

The structure was published by Little, T.H., Zhang, Y., Matulis, C.K., et al., Ramachandran, A., Mayo, K.E., and Radhakrishnan, I., in 2006 in a paper entitled "Sequence-specific deoxyribonucleic Acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely GGCTCAGGGCCACAG, CTGTGGCCCTGAGCC, and Steroidogenic factor 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroidogenic factor 1 P33242 (10-111) (STF1_MOUSE)search Mus musculussearch < 90% 102 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P33242 (10 - 111) Steroidogenic factor 1 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P33242) zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch