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PDBe Entry: 2fdy 
Microsomal P450 2A6 with the inhibitor Adrithiol bound
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OXIDOREDUCTASE
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X-RAY DIFFRACTION
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Resolution: 1.95 Å, R-factor: 21.4%, Free R-factor: 25.0%, Spacegroup: P 1 21 1
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28/11/2006, deposition: 14/12/2005, last revision: 24/02/2009
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Yano, J.K.; Stout, C.D.; Johnson, E.F.
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Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization.
J.MED.CHEM. vol:49, pag:6987-7001 (2006) [PubMed ID 17125252 ]
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CYP2A6, P450 2A6, P450, MONOOXYGENASE, DRUG METABOLIZING ENZYME, COUMARIN 7-HYDROXYLASE, NICOTINE OXIDASE, OXIDOREDUCTASE
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1.14.14.1 ExPASy BRENDA (A B C D)
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Homo sapiens(human) 9606(A B C D)
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Cytochrome P450 2A6 (EC 1.14.14.1) (CYPIIA6) (Coumarin 7-hydroxylase) (P450 IIA3) (CYP2A3) (P450(I)) P11509 (A B C D)
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A, B, C, D
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1z10, 1z11, 2fdu, 2fdv, 2fdw
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| A, B, C, D |
Cytochrome P450 2A6 |
Protein |
P11509 (CP2A6_HUMAN)
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476 |
97% |
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| A, B |
SULFATE ION |
SO4
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| A, B, C, D |
PROTOPORPHYRIN IX CONTAINING FE |
HEM
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| A, B, C, D |
4,4'-DIPYRIDYL DISULFIDE |
D4G
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