2fcw Summary


Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).

The structure was published by Fisher, C., Beglova, N., and Blacklow, S.C., in 2006 in a paper entitled "Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.26 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Alpha-2-macroglobulin receptor-associated protein and Low-density lipoprotein receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-2-macroglobulin receptor-associated protein P30533 (249-357) (AMRP_HUMAN)search Homo sapienssearch 100% 109 97%
B Low-density lipoprotein receptor P01130 (107-186) (LDLR_HUMAN)search Homo sapienssearch < 90% 80 97%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P30533 (249 - 357) Alpha-2-macroglobulin receptor-associated protein Homo sapiens
P01130 (107 - 186) Low-density lipoprotein receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P30533) RAP domainsearch PF06401: Alpha-2-macroglobulin RAP, C-terminal domainsearch
B LDL receptor-like modulesearch Low-density Lipoprotein Receptorsearch Low-density lipoprotein receptor domain class Asearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P30533) endoplasmic reticulumsearch heparin bindingsearch low-density lipoprotein particle receptor bindingsearch

Chain InterPro annotation
A Alpha-2-macroglobulin receptor-associated protein, domain 1search Alpha-2-macroglobulin RAP, C-terminalsearch
B Low-density lipoprotein (LDL) receptor class A repeatsearch Low-density lipoprotein (LDL) receptor class A, conserved sitesearch