2fb8 Summary


Structure of the B-Raf kinase domain bound to SB-590885

The structure was published by King, A.J., Patrick, D.R., Batorsky, R.S., et al., Morrissey, M.M., Tuveson, D.A., and Huang, P.S., in 2006 in a paper entitled "Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of B-Raf proto-oncogene serine/threonine-protein kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A B-Raf proto-oncogene serine/threonine-protein kinase P15056 (445-723) (BRAF_HUMAN)search Homo sapienssearch < 90% 281 92%
B B-Raf proto-oncogene serine/threonine-protein kinase P15056 (445-723) (BRAF_HUMAN)search Homo sapienssearch < 90% 281 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (445 - 723) B-Raf proto-oncogene serine/threonine-protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P15056) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch