Structure of the B-Raf kinase domain bound to SB-590885
The structure was published by King, A.J., Patrick, D.R., Batorsky, R.S., et al., Morrissey, M.M., Tuveson, D.A., and Huang, P.S., in 2006 in a paper entitled "Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of B-Raf proto-oncogene serine/threonine-protein kinase.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: